MDR Tuberculosis - A Global Threat

Vaccine research and development: tuberculosis as a global health threat

One of the aims of the World Health Organisation (WHO) Millennium Development Goals (MDG) is to reduce the number of cases of tuberculosis (TB) infection by the year 2015. However, 9 million new cases were reported in 2013, with an estimated 480,000 new cases of multi-drug resistant tuberculosis (MDR-TB) globally. Bacille Calmette-Guérin (BCG) is the most available and currently used candidate ...

Multi-Drug/Extensively Drug Resistant Tuberculosis (Mdr/Xdr-Tb): Renewed Global Battle Against Tuberculosis?

MDR tuberculosis and non-compliance with therapy.

178 www.thelancet.com/infection Vol 12 March 2012 3 World Health Organization. Towards universal access to diagnosis and treatment of multidrug-resistant and extensively drugresistant tuberculosis by 2015: WHO progress report 2011. http://whqlibdoc.who.int/ publications/2011/9789241501330_eng.pdf (accessed Mar 24, 2011). 4 Upshur R, Singh J, Ford N. Apocalypse or redemption: responding to exten...

MDR, XDR, TDR tuberculosis: ominous progression.

For 2 weeks in January, India coughed and the rest of the world paid attention. Drugresistant tuberculosis (TB), languishing from a decade of neglect by the Indian Revised National Tuberculosis Control Program (RNTCP), was headline news in every Indian newspaper and several international ones as well. What captured local and international attention was a report documenting the isolation of the ...

Epidemiology of Multidrug Resistant Tuberculosis (MDR-TB)

The history of tuberculosis treatment has observed sequential development of resistance to anti-tuberculosis drugs over the decades. Para amino salicylic acid (PAS) and isoniazid (INH) were introduced to reduce the development of streptomycin (SM) resistance, which heralded the era of combination treatment for tuberculosis [1]. Within 20 years, resistance to both INH and SM was already a challe...